Cardioprotective effects of simvastatin‑loaded nano‑niosomes on cardiomyocytes in cardiac ischemia

Background. Cardiac ischemia is the major cause of morbidity and mortality which can be increased by Statins. This study aimed to increase effectiveness simvastatin in form niosomes. Methods. In this study, 25 male Wistar rats were divided into 5 groups: control, (induced closed LAD), receiving nano-niosomes, simvastatin, simvastatin-loaded nano-niosomes. One month after drug injection, RNA was extracted from heart tissue studied groups, cDNA synthesized, a real-time PCR test performed using specific primers. SPSS 21.0 software used for statistical analysis. Analysis variance investigate effect interventions, Tukey's post hoc significant difference (P<0.05) between control groups other as well intervention groups. Results. Apoptosis autophagy significantly group compared (P<0.05). nano-niosomes group, apoptosis showed decrease (P<0.05), also both decrease. Conclusion. Simvastatin an effective recovery cardiac ischemia, but main problem its instability degradability, use niosomes solves properly. Practical Implications. Simvastatin‑loaded nano‑niosomes more reducing damage simvastatin.